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Journal · Label literacy

What 4:1 and 5:1 Actually Mean on a Supplement Label

Extract ratios, standardization and raw powder, explained in plain English — and the four things to check on any label before you buy.

3 min read1 source citedUpdated October 2026

Two bottles. Same herb. Same milligram number on the front. One of them contains several times more plant material than the other. The difference is printed in small type, in a format most buyers have never had explained to them.

The ratio, in one sentence

A 4:1 extract means four parts of raw plant material were concentrated down into one part of finished extract. A 5:1 means five parts became one.

So 100 mg of a 4:1 extract started life as roughly 400 mg of raw plant. 100 mg of a 5:1 started as roughly 500 mg.

It is reduction. Same idea as a stock reducing on the stove — less volume, more concentrated.

The three forms you will see

FormWhat it isWhat to watch
Raw powderThe milled plant, nothing removedNo concentration. Milligrams are the whole story.
Ratio extract (4:1, 5:1)Concentrated by a stated factorTells you concentration, not which compounds survived.
Standardized extractCalibrated to a fixed % of a named marker compoundThe most consistent form, and usually the most expensive.

Standardized is the form most clinical trials use, because a trial needs every capsule to be identical. That is also why a study on a standardized extract does not automatically transfer to a raw powder product — a point worth remembering whenever a brand quotes research.

Which TESTO PLUS ingredients carry a ratio

Six of the nineteen ingredients are concentrated extracts, each with the ratio printed on the panel:

The other thirteen are raw powders, extracts without a stated ratio, amino acids, minerals or food-derived ingredients. Both types are legitimate. What matters is that the label says which is which.

Four checks before you buy anything in this category

  1. Is every amount printed individually? If the panel shows one big number for a “proprietary blend,” you cannot know what is inside it. US rules allow a blend to list only its total weight.1 A large total can hide a dozen ingredients present in trace amounts.
  2. Does the form match the research being quoted? If the marketing cites a study on a standardized extract and the panel lists a raw powder, the research is about a different material.
  3. Is the serving size one tablet or several? Compare like with like. A formula with a large total per serving may simply be spread across two tablets.
  4. Are allergens declared? Marine and shellfish-derived ingredients are common in this category. TESTO PLUS contains shellfish (oyster), and says so.

Why this is published on a brand’s own website

Because every one of those four checks can be run against TESTO PLUS: individual amounts printed, forms and ratios stated, serving size stated, allergen declared. Where a form differs from the one in a study, our research pages say so.

A buyer who knows how to read a panel is a harder buyer to impress and a better one to keep.

TESTO PLUS

Nineteen ingredients, 2,273 mg per serving, every dose printed on the label. Two tablets a day, no caffeine.*

Quick answers

What does a 4:1 extract mean?

Four parts of raw plant material were concentrated down into one part of finished extract. So 100 mg of a 4:1 started as roughly 400 mg of raw plant.

Is a standardized extract better than a raw powder?

It is more consistent — calibrated to a fixed percentage of a named marker compound, which is why trials use it. Both forms are legitimate; what matters is that the label says which is which.

How many TESTO PLUS ingredients are ratio extracts?

Six of the nineteen: Oat Straw 5:1, Stinging Nettle Leaf 5:1, Muira Puama 4:1, Astragalus 4:1, Licorice 4:1 and Oyster 4:1.

Sources

  1. U.S. Code of Federal Regulations, 21 CFR §101.36 — Nutrition labeling of dietary supplements (how ingredients, extracts and proprietary blends must be listed). www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-101/subpart-C/section-101.36

Keep reading

Extract ratios quoted here are printed on the TESTO PLUS Supplement Facts panel. Contains shellfish (oyster).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.